Edward and Alphonse are two brothers who lost their mother to an incurable disease. They miss their mother a lot, and so they try to resurrect her using alchemy. However, they fail at bringing their mother back to life, and on top of that Edward loses his leg. His younger brother Alphonse isn't this lucky -- he loses his entire body. Edward wants to save his brother and so he sacrifices his right arm to attach his brother's soul to an armor suit. Edward wants to get back their original bodies, and so together they begin their journey to find the Philosopher's stone.
This is a retelling from the manga's point of view.