Yukawa Manabu is a genius scientist, of the antisocial kind. Utsumi Kaoru must socialise because her job as a detective involves dealing with people. Together, they set out to solve the strangest mysteries through mere scientific means.
Both feature a professional who helps solve cases with his expertise. One is about a physics professor who help the police on various cases, while the other is about a locksmith who helps the police solve locked room mysteries. Both professionals are uninterested in the culprit and attempt to solve only the mystery of how the crime was committed. The rest is left up to the police detectives.